| 1 | Atlético Bucaramanga (COL) | L | Patriotas Boyacá (COL) | 2017-08-19 |
| 2 | Aguilas (COL) | L | Tigres F.C (COL) | 2017-08-19 |
| 3 | Jaguares de Córdoba (COL) | L | Envigado FC (COL) | 2017-08-20 |
| 4 | Cruzeiro EC (BRA) | L | Sport Club de Recife (BRA) | 2017-08-20 |
| 5 | Inter (ITA) | L | Fiorentina (ITA) | 2017-08-20 |
| 6 | Udinese Calcio (ITA) | V | Chievo Verona (ITA) | 2017-08-20 |
| 7 | Tigres UANL (MEX) | L | Pumas UNAM (MEX) | 2017-08-19 |
| 8 | Cruz Azul FC (MEX) | L | Atlas FC (MEX) | 2017-08-19 |
| 9 | Veracruz (MEX) | E | Queretaro (MEX) | 2017-08-19 |
| 10 | Vitoria Setubal (POR) | E | GD Chaves (POR) | 2017-08-20 |
| 11 | Colorado Rapids (USA) | V | DC United (USA) | 2017-08-19 |
| 12 | Earthquakes S.J. (USA) | E | Philadelphia Union (USA) | 2017-08-19 |
| 13 | Kansas City (USA) | L | FC Dallas (USA) | 2017-08-19 |
| 14 | Montreal Impact (CAN) | L | Real Salt Lake (USA) | 2017-08-19 |
