| 1 | Valledupar FC (COL) | V | Unión Magdalena S.A (COL) | 2017-10-14 |
| 2 | Cúcuta Deportivo FC (COL) | E | Leones FC (COL) | 2017-10-15 |
| 3 | Real Santander CD (COL) | L | Fortaleza (COL) | 2017-10-15 |
| 4 | Real Betis (ESP) | V | Valencia (ESP) | 2017-10-15 |
| 5 | Eibar (ESP) | E | Deportivo (ESP) | 2017-10-15 |
| 6 | Tenerife (ESP) | E | Numancia de Soria (ESP) | 2017-10-14 |
| 7 | Bayer Leverkusen (ALE) | E | Wolfsburg (ALE) | 2017-10-15 |
| 8 | Velez Sarsfield (ARG) | L | Newells Old Boys (ARG) | 2017-10-14 |
| 9 | Guingamp (FRA) | L | Stade Rennais FC (FRA) | 2017-10-14 |
| 10 | Burdeos (FRA) | E | FC Nantes (FRA) | 2017-10-15 |
| 11 | Derby Country FC (ING) | L | Nottingham (ING) | 2017-10-15 |
| 12 | Inter (ITA) | L | Milan (ITA) | 2017-10-15 |
| 13 | Pistoiese (ITA) | E | Lucchese (ITA) | 2017-10-15 |
| 14 | San Francisco Deltas FC (USA) | L | Puerto Rico FC (USA) | 2017-10-14 |
